These results indicate that, in KDF1-overexpressing LUAD cells, the STAT3 pathway is on the upstream of the AKT pathway and, by activating the STAT3 pathway and later AKT and other STAT3 downstream pathways, the expression levels of KDF1 in the cancer cells correlated positively to the levels of p-STAT3 in the cells. The gene discussed is KDF1; the disease is cancer.