Activated platelets that adhere, aggregate, and degranulate in injured tissue express increased CD62P, which is known as platelet activation marker; platelets are activated by histamine, oxygen radicals, interleukin 1(IL-1), and tumor necrosis factor (TNF), and cytokines such as IL-1 and TNF are increased in sepsis [35,36]. The gene discussed is TNF; the disease is Sepsis.