The flow cytometry analysis of tumor-derived single-cell suspensions revealed a decreased percentage of CD31+/GP38- blood vascular endothelial cells (BEC) and CD31+/GP38+ lymphatic endothelial cells (LEC) in WT tumor-bearing mice treated with TMI-5, in NOX1-deficient mice and NOX1-deficient mice treated with TMI-5, as compared to vehicle-treated-WT mice (Figure 3B). This evidence concerns the gene PDPN and neoplasm.