To test these hypotheses, we monitored NOX1, ADAM17, and mMCAM protein expression and performed co-immunoprecipitation (co-IP) experiments from whole lysates of human endothelial cells (HUVEC) and human colorectal cancer (CRC) cell lines (HCT-116, DLD1, and SW480). The gene discussed is NOX1; the disease is colorectal carcinoma.