Mean concentrations of IGF-1 circulating levels were lower in patients with CRC (123.1 ± 59.6 ng/mL) than they were in controls (213.6 ± 219.3 ng/mL) (p = 0.001), while mean concentrations of IGFBP-2 were higher in patients (1041.2 ± 756.8 ng/mL) than in controls (813.3 ± 528.0 ng/mL) (p = 0.002). This evidence concerns the gene IGFBP2 and colorectal carcinoma.