The common dysfunctional variants of the ABCG2/BCRP gene, rs72552713 (p.Q126X) and rs2231142 (p.Q141K), have been identified as the main genetic cause of the common form of the disease (that is, primary gout/hyperuricemia) [51,55] as well as early-onset gout [56]. This evidence concerns the gene ABCG2 and hyperuricemia.