To investigate the function of FNDC3B in GBM cells, we constructed three types of FNDC3B-siRNA (siFNDC3B) and a scrambled non-specific control siRNA (siCtrl), tested FNDC3B gene silencing on U87MG cells (Figure S1), and used the most effective siFNDC3B (siFNDC3B No. 1, Table S3) in the subsequent experiments to investigate FNDC3B function. Here, FNDC3B is linked to glioblastoma.