Within brain tumor tissues, we observed that FNDC3B expression levels progressively increased from Grade 2 to Grade 4 (Grade 2, 2.2-fold, p < 0.0001; Grade 3, 2.7-fold, p < 0.0001; Grade 4, 3.6-fold, p < 0.0001). This evidence concerns the gene FNDC3B and brain neoplasm.