CD274 and hepatocellular carcinoma: It has been reported that IL-1 β increased the level of SLC7A11, then up-regulated the expression of PD-L1 and CSF1 by regulating α-KG/HIF1 α and promoted the infiltration of tumor-related macrophages and myeloid suppressor cells to increase the metastasis of hepatocellular carcinoma [41].