AST was found to mitigate tauopathy and astrogliosis by activating the neuroprotective arm ACE2/Ang1-7/Mas receptor pathway, as well as the neuroprotective proteins PI3K p85/p55 and p35 while inhibiting AngII and the Notch1/NICD/NF-κB pathway. This evidence concerns the gene NOTCH1 and tauopathy.