Contrary to expectations, MK4 via SXR activation, in a high phosphate medium, appeared to accelerate warfarin calcification in human aortic valve interstitial cells from patients with calcified aortic valve stenosis [59], while in cells taken from non-calcified aortic valves, the SXR agonist warfarin did not cause calcification [60]. Here, NR1I2 is linked to stricture.