AKT1 and neoplasm: In this context, tanshinone IIA may suppress proliferation in A549, a human non-small cell lung cancer cell line, decrease the expression of VEGF and VEGF receptor 2 (VEGFR2) in tumor cells, indirectly inhibiting the downstream PI3K/AKT signaling pathway, downregulating the expression of the anti-apoptosis gene, thereby inhibiting the growth of tumor cells as a consequence of cell apoptosis.