PFKFB3 and psoriasis: 3PO, 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one, an antagonist of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB3), an enzyme controlling a limiting step in glycolysis, prevented the development of imiquimod-induced T cell-mediated delayed-type hypersensitivity and psoriasis in mice [131].