TLR7 and endothelial dysfunction: Furthermore, the expansion of Treg cells through low-dose IL-2 has been shown to alleviate hypertension in NZBWF1 mice [80], while the neutralization of IL-17, the primary proinflammatory cytokine produced by Th17 cells, has been found to ameliorate endothelial dysfunction and reduce high blood pressure in SLE mice induced by TLR7 activation [18].