The polymorphisms of ERCC5 rs873601 (Additive model: p = 0.031; Dominant model: p = 0.027), PNKY rs2444933 (Recessive model: p = 0.007), and PNKY rs1869641 (Recessive model: p = 0.028) were significantly associated with the PFS in SCLC patients. This evidence concerns the gene ERCC5 and small cell lung carcinoma.