One of the main mechanisms responsible for hypertension in overt Cushing’s syndrome is the saturation of the 11b-hydroxysteroid-dehydrogenase type 2 (11b-HSD2) enzyme due to high levels of cortisol, leading to cortisol binding to the mineralocorticoid receptor, causing sodium retention, volume expansion and hypertension [24]. This evidence concerns the gene NR3C2 and Hypertension.