A study [43] indicated that differential proteomic profiling revealed that KLK6 re-expression resulted in significant down-regulation of vimentin, which represented an established marker of epithelial-to-mesenchymal transition of tumor cells and the concomitant up-regulation of calreticulin and epithelial markers cytokeratin 8 and 19, indicating that KLK6 might play a protective role against tumor progression that was likely mediated via the inhibition of epithelial-to-mesenchymal transition. This evidence concerns the gene VIM and neoplasm.