Enriched genes including CX3CR1 [441], S100A12 [442], PF4 [443], MPO (myeloperoxidase) [444], WNT7A [445], SLC6A4 [446], BDNF (brain derived neurotrophic factor) [447], CXCL10 [448], NEK7 [449], CYP1B1 [450], ABCA3 [451], TRIB3 [452], PCSK9 [453], FGF2 [454], ACKR4 [455], FASN (fatty acid synthase) [456], VIP (vasoactive intestinal peptide) [457], KL (klotho) [458], BMPR2 [459], APOA1 [323], TLR3 [460], CCR2 [461], TLR7 [462], CAV1 [463], WWC2 [464], TFPI (tissue factor pathway inhibitor) [465], EPAS1 [466], and CCDC40 [467] were identified to be associated with pulmonary hypertension. The gene discussed is TLR3; the disease is pulmonary arterial hypertension.