Because reelin regulates the neuroblast cytoarchitecture, including the migration and positioning of pyramidal neurons, interneurons, and Purkinje cells, and, after birth, still modulates synaptic plasticity, it has become one of the obvious candidates for a neurodevelopmental hypothesis of schizophrenia [77,78,79,80,81,82]. This evidence concerns the gene RELN and schizophrenia.