RELN and schizophrenia: Proteins of virtually the entire reelin metabolic pathway have been linked with genetic studies to transcription factors including NPAS1 (Neuronal PAS 1) [111], NPAS3 (Neuronal PAS domain protein 3) [112], and TBR1 (T-box brain transcription factor 1) [113]; enzymes such as MTHFR (5,10-methylenetetrahydrofolate reductase) [114]; and receptors such as NMDA (N-methyl-D-aspartate) [115], which are considered as gene candidates for schizophrenia.