Reports indicate reelin’s potential role in schizophrenia development, possibly due to its impact on the laminar structure of the cortex and synaptic signaling, which in turn would result in changes in the expression of reelin in the CNS and serum as well as changes in the expression of its receptors during treatment [26,27,28,29,30,31,32,45]. This evidence concerns the gene RELN and schizophrenia.