Human BMSC-derived exosomes inhibited the activation of the phosphatidylinositol-3 kinase (PI3K)/protein kinase B (Akt)/ nuclear factor-kappa B (NF-kB) signaling pathway and maintained Th17/Treg balance, which, in turn, suppress aneurysm formation [89]. This evidence concerns the gene AKT1 and aneurysm.