The expressions of TLR2, MyD88, and NF-kB p65 in patients with intracranial aneurysms are significantly higher compared to normal controls, which is why Zhang et al. proposed the TLR2/4-MyD88-NF-kB signaling pathway to be involved in the pathogenesis of intracranial aneurysms [32]. Here, TLR2 is linked to Dilatation of the cerebral artery.