Through these findings, we can propose that the APOE ε4 allele may contribute to the genesis of cognitive impairment in patients with long-term COVID-19 since it protects less against COVID-19 infection and stimulates a pro-inflammatory response in patients with COVID-19, reducing endothelial repair and antioxidant activity in these patients and inducing greater microglial activation. The gene discussed is APOE; the disease is Cognitive impairment.