CNV sequencing can be used for the detection of losses/gains at a single locus, e.g., HER2/Neu gene amplification in breast tumors, codeletion of 1p and 19q in oligodendrogliomas, and of complex chromosomal alterations (large amplifications and/or deletions) [12,14]. The gene discussed is ERBB2; the disease is oligodendroglioma.