However, an increasing number of gene fusions have been shown to be non-histotype-specific and are shared by different tumor types that are otherwise clinically or phenotypically completely unrelated (e.g., the EWSR1–CREB1 gene fusion in angiomatoid fibrous histiocytoma, clear cell sarcoma, hyalinizing clear cell carcinoma of the salivary gland, and primary pulmonary myxoid sarcoma). The gene discussed is EWSR1; the disease is clear cell sarcoma.