Moreover, the membrane HER2 receptor (erbB-2 receptor tyrosine kinase 2) when bound to EGFR can also activate tyrosine kinases signalling pathways RAS/RAF/ERK, PIK3K/AKT/mTOR, JAK/STAT3 producing a hyperactivation of mitogenic signals leading to uncontrolled cell proliferation and tumorigenesis in CRC [126]. Here, EGFR is linked to colorectal carcinoma.