Heterozygous pathogenic deletions, frameshift, splice-site, missense and 3′-UTR variants cause hereditary spastic paraplegia type 31 (SPG31) [19] and a splice-site variant hereditary motor neuronopathy 12 (HMND12; OMIM 614751) [20]. Here, SPRR2A is linked to hereditary spastic paraplegia 31.