Similarly, cg17075888, cg26823705, and cg10217853 within PDK4, NBPF20, and ARRDC4, respectively, showed significant hypomethylation, whereas cg04816311, cg16740586, cg19750657, and cg00683922 located within C7orf50, ABCG1, UFM1, and PFKFB2 displayed significant hypermethylation in patients with T2DM, respectively. Here, PFKFB2 is linked to type 2 diabetes mellitus.