HLA-DRB1 and neuromyelitis optica: In this study, the authors found that the class II HLA alleles were associated with NMO development (HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06, and -DQB1*04:02) in individuals belong to a Native American ancestry (instead of European lineage, which is also diffuse in Latin American populations).