In particular, in case 2, the demonstration of Myc involvement together with BCL6 represents a crucial finding that could help to potentially better classify the disease as a double-hit lymphoma, also known as high-grade B-cell lymphoma, an uncommon and more aggressive subtype of DLBCL characterized by a worse prognosis [35]. The gene discussed is BCL6; the disease is B-cell non-Hodgkin lymphoma.