Due to the pleiotropic nature of STXBP1, it has become one of the most identified variants of concern, with a recent study of 150 children with EIEE identifying STXBP1 variants in 6% of infantile onset epilepsy patients, and 10% of neonatal onset epileptic encephalopathy [3]. Here, STXBP1 is linked to infantile-onset epilepsy.