Although Wang et al. [22] did not identify functional ATG16L1 genetic variants or factors regulating ATG16L1 gene expression, some significant particularities have been observed with respect to locus 4 as follows: (1) they contain the mutated form (rs77820970 T); (2) they belong to the molecular architecture of the hap4, hap5, hap6 and hap7 haplotypes, found only in patients; and (3) this locus explains much of the genetic divergence between the controls and PD. The gene discussed is ATG16L1; the disease is Parkinson disease.