In Tohoku Hospital Pediatrics-1 (THP-1) acute monocytic leukemia after treatment of macrophages with oxidized low-density lipoprotein (ox-LDL) as an atherosclerotic cell model, miR-217 was found to target SIRT1 affecting downstream inflammatory responses, contributing, thus, to atherosclerosis progression [18]. This evidence concerns the gene SIRT1 and atherosclerosis.