NOS3 and Hyperglycemia: A study in umbilical vein endothelial cells (HUVEC) revealed that endogenous Alu RNA accumulation during hyperglycemia induced oxidative stress and malfunction in the endothelial cells by inhibiting the expression of superoxide dismutase 2 (SOD2) and endothelial nitric oxide synthase (eNOS) at both the transcription and translation levels through the NFκB signaling pathway.