TXNIP and type 1 diabetes mellitus: Specifically, DNAm at cg19693031 (Chr 1, Thioredoxin-Interacting Protein (TXNIP)) and cg21534330 (Chr 17, Casein Kinase 1 Isoform Delta) was found to have an inverse relationship with concurrent HbA1c, suggesting that lower methylation levels of TXNIP are linked to poorer glycemic control in T1D [50].