Also, a genome-wide analysis of the DNA methylation quantitative trait locus (mQTL) in human pancreatic islets revealed 383 CpGs (0.08% of tested CpGsites), showing significant associations including known diabetes loci, e.g., ADCY5, KCNJ11, HLA-DQA1, INS, PDX1 and GRB10. This evidence concerns the gene ADCY5 and diabetes mellitus.