PIK3CA and vascular malformation: The authors defined three categories of PIK3CA-related conditions: (A) PIK3CA-realted overgrowth spectrum disorders (PROS), characterized by overgrowth of the affected tissues; (B) exclusive vascular proliferation, named PIK3CA-related vascular malformations; (C) exclusive non-vascular proliferation, named PIK3CA-related non-vascular lesions [2].