CD8A and colorectal carcinoma: Similarly, in oligo-metastatic lesions evolving towards a poly-metastatic disease after surgical removal of single-nodule liver metastases from CRC, patients exhibited scarce granzyme-B CD3+ CD8+ cells (27.6 + 2.7 per mm2) compared to those without relapse at three years (58.6 + 8.6 per mm2; p = 0.0270) assessed through IHC [16].