More studies have emerged in colorectal cancer (CRC), where molecular subtyping (“canonical” and “immune” subtypes) [48], regression of key-driver gene mutations (KRAS, PIK3CA) [16], high levels of T-cell infiltration into metastases, and specific gene mutations (ERBB2) have been correlated with the OMD phenotype [15]. Here, KRAS is linked to colorectal carcinoma.