The most common manifestations are sparse, curly, fine, brittle slow-growing hair; sparse to absent eyebrows with ulerythema ophryogenes; sparse to absent eyelashes; dystrophic rapid-growing nails; skin abnormalities such as keratosis pilaris, hyperkeratosis, ichthyosis, eczemas, xerosis, hemangiomas and numerous pigmented naevi (more common in patients with BRAF mutations) [33,34,35,36]. This evidence concerns the gene BRAF and ulerythema ophryogenesis.