PNPLA2 and keratoconus: In a recent GWAS, McComish et al. identified two SNPs, rs61876744 located in the intronic region of the PNPLA2 (patatin-like phospholipase domain–containing 2) gene and rs138380 near the CSNK1E (casein kinase I isoform epsilon) locus reaching a genome-wide significance for association with KC in populations of European ancestry [15].