The frequency of rs6187674 (T) allele in PNPLA2 was lower in KC (0.33) than in controls (0.43) and exhibited a significant protective effect against KC (OR = 0.64, 95% CI = 0.44–0.93, p = 0.020) but did not survive Bonferroni’s correction for multiple testing. Here, PNPLA2 is linked to keratoconus.