These pathways contained spinocerebellar ataxia, Huntington’s disease, Parkinson’s disease and pathways of neurodegeneration of multiple diseases (shown in Table S2), and some potential genes, including RNA polymerase II subunit J (POLR2J), huntingtin interacting protein 1 (HIP1), frizzled class receptor 9 (FZD9), ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 (ATP2A3), ubiquitin-conjugating enzyme E2 G1 (UBE2G1) and insulin receptor substrate 1 (IRS1), were enriched. Here, IRS1 is linked to Huntington disease.