CD274 and non-small cell lung carcinoma: Importantly, these findings were confirmed in a recent retrospective study that enrolled patients with advanced NSCLC treated with ICI, which showed that combining TMB, PD-L1 expression, and NLR improves the accuracy of predicting the ORR, time to disease progression, and OS compared to the TMB when evaluated alone, highlighting again the importance of a combined biomarker approach [127].