In this study, we aimed to determine the frequencies of PPAR-γ2 rs1801282 (Pro12Ala) and PPAR-β/δ rs2016520 (+294T/C) polymorphisms and their relation to anthropometric and metabolic biomarkers in adults with T2D from Chihuahua, Northern Mexico. The gene discussed is PPARG; the disease is type 2 diabetes mellitus.