Since the discovery of the first gene associated with ALS, superoxide dismutase 1 (SOD1) [260], more than 20 other genes have been reported to correlate with its pathogenesis, including matrin 3 (MATR3), coiled-coil-helix-coiled-coil-helix domain-containing 10 (CHCHD10), fused in sarcoma/translocated in liposarcoma (FUS), chromosome 9 open reading frame 72 (C9orf72), TAR DNA binding protein 43 (TDP-43), and OPTN, among others [261]. Here, MATR3 is linked to amyotrophic lateral sclerosis.