PROM1 and neoplasm: The fluorescence and PET imaging probes were separately produced by conjugating Alexa 680 dye (Alexa 680-AC133 mAb) or 64Cu-NOTA radiopharmaceutical (64Cu-NOTA-AC133 mAb) to the AC133 antibody, which was designed to bind to tumor stem cell-overexpressing AC133 antigen.