For this purpose, we assessed the relationship between serum Vit D levels and acute phase reactants such as CRP, fibrinogen and ferritin and pro-inflammatory markers such as IL-1β, IL-6, IL-8, TNF-α, NF-κB and MAPK in newly diagnosed prediabetes and type 2 DM patients. This evidence concerns the gene NFKB1 and prediabetes syndrome.