This study was based on a single blood measurement, which may not accurately represent the concentrations of circulating inflammatory parameters throughout time, and the serum IL-1β, IL-6, IL-8, TNF-α, NF-κB and MAPK levels should be assessed at different stages to better understand their function in the pathogenesis of T2DM. This evidence concerns the gene NFKB1 and type 2 diabetes mellitus.