CXCL8 and type 2 diabetes mellitus: This study revealed that the IL1-β, IL-6, IL-8, TNF-α, NF-κB and MAPK levels as pro-inflammatory markers and CRP, fibrinogen and ferritin as serum acute phase reactants were significantly increased in the prediabetes and T2DM groups compared to nondiabetes group (Table 1).