LGALS3 and cancer: The binding of galectin-3 to β1,6GlcNAc-branched N-glycans on β4 integrin induces the formation of a supramolecular complex consisting of α6β4 integrin, EGFR, and laminin-332, which in turn promotes cancer cell adhesion and migration via the activation of PI3K and ERK signaling pathways [15,34].