Another extensively studied channel family, firmly associated with cell volume control and GBM migration and invasion, is that of the Ca2+-activated K+ (KCa) channels, which includes the large-conductance (~250 pS) (KCa1.1, or BK), the intermediate (20–80 pS; KCa3.1 or IK) and the small-conductance (12–20 pS; KCa2.1–2.3 or SK 1–3) channels [64]. Here, IK is linked to glioblastoma.