In the cell line DT40, a chicken B-cell lymphoma derived from the bursa of Fabricius, it was reported that Lyn and the unrelated non-SFK tyrosine kinase Syk (Syk family) were absolutely necessary for activation of Ca2+-release-activated Ca2+ channels (CRAC) after emptying the intracellular Ca2+ stores, and this effect was not due to the increased expression of the Orai1 channel or the STIM1 Ca2+ sensor, but to unknown phosphorylation events mediated by these tyrosine kinases in order to maintain the function of the involved target proteins [137]. This evidence concerns the gene SYK and B-cell non-Hodgkin lymphoma.