Using human mammary epithelial cells and MCF7 adenocarcinoma cells, it was shown that the NFAT1 activation by the Wnt-5a/Ca2+ pathway was suppressed via a pathway involving Wnt-5a, the SFK c-Yes, Cdc42 (clone derived 42), and CK1α (casein kinase 1α), where c-Yes, but not c-Src or c-Fyn, had been activated by Wnt-5a [132]. This evidence concerns the gene YES1 and adenocarcinoma.