In a study performed with glioblastoma cell lines, it was shown that the tyrosine kinase inhibitor tyrphostin A9 (also known as malonoben), in addition to inhibiting EGFR and other tyrosine kinase receptors, also inhibited Pyk2; reduced glioblastoma cell proliferation and migration; and induced cell death by apoptosis [158]. The gene discussed is PTK2B; the disease is glioblastoma.