In an apparently conflicting report using STIM1-knockout prostate cancer cells, it was proposed that Ca2+ entry via SOCE was not required for the activation of CaMK-II and the c-Src/MAPK pathway, and it instead appeared that STIM1 was a downstream target of the c-Src/MAPK pathway because ERK1/2 had phosphorylated STIM1 [117]. This evidence concerns the gene STIM1 and prostate cancer.