MMP2 and neoplasm: Similarly, using human ductal pancreatic PaCa tumor cells, it was shown that eEF-2K controlled the activity of c-Src via tissular transaminase-2, inducing cell proliferation, increased motility, extracellular proteolysis by matrix metallopeptidase-2 (MMP-2), and, thus, the invasion and dissemination of tumor cells (see Figure 4C).