In addition to this CaM-mediated mechanism, it was demonstrated that the activation of PKC with phorbol ester promoted c-Src activation, and the active kinase was shown to interact with ADAM10, where c-Src appeared to compete with CaM for ADAM10 binding [121,122], further promoting the activation of the proteinase, inducing the cleavage of adhesion molecules, and increasing the invasiveness of the tumor cells. This evidence concerns the gene ADAM10 and neoplasm.