STIM1 and melanoma: In a melanoma cell line, it was demonstrated that the chemical ablation of lipid rafts negatively affected the Ca2+ entry into the cell via a mechanism named store-operated Ca2+ entry (SOCE), which started after the depletion of Ca2+ in the lumen of the endoplasmic reticulum, and it was mediated by the stromal interaction molecule 1 (STIM1)/Orai Ca2+-channel system (see Figure 1D).