Figure 2a–d, respectively, illustrate the dynamics of changes in the concentration of sGAGs, CS/DS, HS, and HA in the urine of children with JIA both before (T0) and after 3 (T3), 6 (T6), 12 (T12), 18 (T18), and 24 (T24) months of applying ETA, accepting as a starting value the concentration of glycans shown in the urine of the afflicted children before the first dose of the TNF-α inhibitor (T0). Here, TNF is linked to juvenile idiopathic arthritis.