SHH and central nervous system neoplasm: MB is mostly localized in the cerebellum [47] with a peak incidence of around five years of age and is classified into four principal molecular groups (wingless activated (WNT), sonic hedgehog (SHH) activated, and non-SHH/WNT Group 3 and 4), according to the 2021 WHO Classification of Tumors of the CNS [48].