CD4 and cancer: Interestingly, the high-risk group demonstrated significantly decreased infiltration for three cell types (T cells CD8, T cells CD4 memory activated, and macrophages M1) that are key anti-cancer immune cells, increased for another 5 cell types (B cells naïve, T cells CD4 memory resting, monocytes, dendritic cells activated, and mast cells resting), and unchanged for the rest 14 cell types (Figure 6E), suggesting a nonidentical tumor immune microenvironment.