As such, results from two cohorts, the Québec Family Study and the Swedish Obese Subjects, concluded that Trp64Arg mutation in β3-AR gene was not associated with cardiometabolic insults, obesity, adiposity, or body composition change over the period of 12 years in the former. The gene discussed is ADRB3; the disease is obesity due to melanocortin 4 receptor deficiency.