Of note are two CASQ1 mutations, one correlated with malignant hyperthermia (CASQ1 M87T), and a second one involved in tubular aggregate myopathy, which have been grouped in between the non-dimerizing and the dimerizing variants because their position possibly disrupts either the dimerization or the polymerization interfaces (Table 1). This evidence concerns the gene CASQ1 and tubular aggregate myopathy.