Specific DNAme changes are also observed in atherosclerosis and cardiovascular disease (e.g., ABCG1), metabolic disorders (e.g., ANKRD26, IGF2), Alzheimer’s disease, and other nervous system disorders (e.g., IGF2) [36,37,51,52,53,54,55,56,57,58,59,60]. This evidence concerns the gene IGF2 and early-onset autosomal dominant Alzheimer disease.