Our findings were striking, as we observed pronounced expression of TGF-β1 and IL-6 in both the upper and lower regions of the corpus glands, extending even to the invasion zone, as depicted in Figure 6B. These findings strongly suggest that the loss of two crucial tumor suppressor genes, LKB1 and PTEN, not only fosters unbridled cell proliferation but also triggers a significant and noteworthy inflammatory response within the murine stomach. This evidence concerns the gene TGFB1 and neoplasm.