One patient had concomitant KRAS p.A59E mutated histiocytic sarcoma and CMML, one patient had synchronous NRAS p.G12V mutated indeterminate cell histiocytosis and CMML and finally, one patient had subsequent NRAS p.Q61R mutated ECD and AML [72]. This evidence concerns the gene NRAS and chronic myelomonocytic leukemia.