Feng et al. found that during extracorporeal radiation therapy (EBRT) in patients with prostate cancer, in addition to proinflammatory factors IL-8, IL-16, IFN-α2, and IFN-γ, IL-10, IL-3, IL-9, IP-10, and SDF-1α were also positively correlated with changes in fatigue scores from T1 (before the start of EBRT) to T3 (one year after EBRT), which can be used as early biomarkers to predict chronic fatigue [37]. Here, IL16 is linked to Familial prostate cancer.